US Open 2016: Garbine Muguruza and Milos Raonic knocked out in round two

Muguruza has only reached one final in 2016 - when she won the French Open

French Open champion Garbine Muguruza and Wimbledon finalist Milos Raonic made shock exits in the second round of the US Open.

Canada's Raonic, the fifth seed, struggled physically as American qualifier Ryan Harrison - the world number 120 - won 6-7 (4-7) 7-5 7-5 6-1. Spanish third seed Muguruza lost 7-5 6-4 to Latvia's Anastasija Sevastova.


Top seed Novak Djokovic reached round three without hitting a ball as Jiri Vesely withdrew before their match. The Czech, 23, said he was "very, very disappointed" to pull out with inflammation of his left forearm.

Defending champion Djokovic, who has been struggling with a wrist injury, gets three days off before facing Russia's Mikhail Youzhny on Friday.

Former champion Marin Cilic and French seeds Gael Monfils and Jo-Wilfried Tsonga progressed, with fourth seed Rafael Nadal to play Italy's Andreas Seppi later on Wednesday.